Research interests

While I was at Columbia, my research interests lay in the application of integrated circuit (IC) design in non-traditional areas. The integration of electronics and biology typically yields a performance gain not possible with disparate systems.

At Columbia, I worked on high-bandwidth solid-state nanopore DNA sequencing platforms. Nanopore based sequencing platforms are among the frontrunners for the third generation of sequencing platforms. One of the biggest issues with nanopore based sequencing, however, is the high translocation rate of DNA through the pore. The aim of this work is to develop high bandwidth low-noise instrumentation amplifiers that are tightly integrated with the pore in order to improve the temporal resolution of nanopore based measurements.

Publications

Measurement of DNA Translocation Dynamics in a Solid-State Nanopore at 100 ns Temporal Resolution
Siddharth Shekar, David Niedzwiecki, Chen-Chi Chien, Peijie Ong, Daniel A. Fleischer, Jianxun Lin, Jacob K. Rosenstein, Marija Drndić, Kenneth L. Shepard
Nano Letters, 2016 16 (7), 4483-4489
Link PDF

Single-channel recordings of RyR1 at microsecond resolution in CMOS-suspended membranes
Andreas J.W. Hartel, Peijie Ong, Indra Schroeder, M. Hunter Giese, Siddharth Shekar, Oliver B. Clarke, Ran Zalk, Andrew R. Marks, Wayne A. Hendrickson, Kenneth L. Shepard
PNAS, 2018 115 (8), E1789-E1798
Link PDF

CMOS-integrated low-noise junction field-effect transistors for bioelectronic applications
Daniel A. Fleischer, Siddharth Shekar, Shanshan Dai, Ryan M. Field, Jenifer Lary, Jacob K. Rosenstein, Kenneth L. Shepard
IEEE Electron Device Letters, 2018 39 (7), 931-934
Link PDF

Wavelet denoising of high-bandwidth nanopore and ion-channel signals
Siddharth Shekar, Chen-Chi Chien, Andreas J.W. Hartel, Peijie Ong, Oliver B. Clarke, Andrew R. Marks, Marija Drndic, Kenneth L. Shepard
Nano Letters, 2019 19 (2), 1090-1097
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High bandwidth approaches in nanopore and ion-channel recordings - A tutorial review
Andreas J.W. Hartel, Siddharth Shekar, Peijie Ong, Indra Schroeder, Gerhard Thiel, Kenneth L. Shepard
Analytica Chimica Acta, 2019
Link PDF

A miniaturized multi-clamp CMOS amplifier for intracellular neural recording
Siddharth Shekar, Krishna Jayant, M. Angeles Rabadan, Raju Tomer, Rafael Yuste, Kenneth L. Shepard
Nature Electronics, 2019 2 (8), 343-350
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Single-stranded DNA translocation recordings through solid-state nanopores on glass chips at 10 MHz measurement bandwidth
Chen-Chi Chien, Siddharth Shekar, David J. Niedzwiecki, Kenneth L. Shepard, Marija Drndic
ACS Nano, 2019 13 (9), 10545-10554
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Patents

Shield electrode for input device
Daniel Jacob Benjamin Bechstein, John Stephen Smith, Siddharth Shekar, Teera Songatikamas, Elvis Mwenda Kibiti, Jared A. Brauner, Lindsay Diane Rego Corbet, Wang Chung Alston Cheung, Vipin Ayanoor-Vitikkate, Nitin Sitaraman, Joyan Gratian Sanctis, Blake R. Marshall
U.S. patent US11460933B2, Oct. 4 2022
Link